Thyroid Zen Defense

Thyroid Zen Defense 120 caps (77500) Generally, Thyroid Zen Defense provides Targeted Thyroid and Stress Response Support with Adaptogens and Immune-Modulating Nutrients* What It Does Specifically, this formula delivers clinically studied nutrients and botanicals that support: firstly, thyroid function, secondly, stress resilience, and thirdly, immune system balance.* It especially targets the intersection of the hypothalamic-pituitary-thyroid (HPT) axis and stress physiology; i.e. it promotes healthy hormone synthesis, immune surveillance, and adaptive responses.* How It Works • Holy Basil (Holixer® extract): Clinically shown to reduce perceived stress and support cortisol balance, this adaptogen helps buffer stress-related disruptions to the HPT axis.*[1] • Myo-Inositol Selenium: In combination, this duo has been shown in multiple trials to support thyroid hormone biosynthesis and regulation more effectively than selenium alone.*[2–5] • Myo-Inositol: Supports iodine uptake and organification, essential for thyroid hormone production in thyrocytes.*[4] • Selenium: A cofactor for deiodinase and antioxidant enzymes (glutathione peroxidases, thioredoxin reductases), selenium protects thyroid tissue from oxidative stress and modulates immune signaling.*[5–7] • Shiitake Mushroom (Lentinula edodes): Provides immunomodulatory beta-glucans and polysaccharides that influence natural killer (NK) cell activity, supporting immune surveillance and thyroid-immune interaction.*[8,9] • Immune-Thyroid Interactions: NK cell activity plays a regulatory role in thyroid function, particularly during aging and times of immune activation.*[10] Who It’s For Especially designed for individuals seeking stress resilience and thyroid balance, particularly those seeking optimal thyroid health, stress response balance, or immune-thyroid axis support. Special Features Overall, provides a cohesive formula aimed at the triad of stress, thyroid, and immune health.* References 1. Lopresti AL, et al. Front Nutr. 2022;9:965130. doi:10.3389/fnut.2022.965130 2. Ferrari SM, et al. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):36–42. 3. Pace C, et al. Endocr J. 2020;67(11):1093–1098. 4. Paparo SR, et al. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756 5. Nordio M, Basciani S. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51–59. 6. Wang F, et al. Front Endocrinol (Lausanne). 2023;14:1133000. doi:10.3389/fendo.2023.1133000 7. Pirola I, et al. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(1):28–35. 8. Bisen PS, et al. Curr Med Chem. 2010;17(22):2419–2430. 9. Roszczyk A, et al. Int J Mol Sci. 2022;23(16):8980. doi:10.3390/ijms23168980 10. Lee EK, Sunwoo JB. Endocrinol Metab (Seoul). 2019;34(2):132–137 Ingredients: Serving Size: 2 capsules Servings Per Container: 60 Amount per serving: Selenium (as L-selenomethionine): 83 mcg Myo-Inositol: 600 mg Holy Basil Extract  (as Holixer™ Ocimum sanctum leaf extract,  standardized to > 5% Ocimum Bioactive Complex): 125 mg Shiitake Extract 4:1 (Lentinula edodes, fruiting body): 500 mg Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate. Suggested use: As a dietary supplement, take 2 capsules twice daily, or as directed by a healthcare practitioner. Finally – Warning: If you are pregnant or lactating, have any health conditions or are taking any medication, consult your healthcare practitioner before use. Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.